This, along with the accepted concept of c-Myc addiction in MM [29] and the data from patient arrays showing SGPP1 gene expression decreasing with the disease progression and inversely correlating with GFI1 and c-Myc gene expression, prompted us to hypothesize that GFI1 transcriptional repression of SGPP1 contributes to elevated c-Myc in MM cells. The gene discussed is SGPP1; the disease is Miyoshi myopathy.