TDG and hepatocellular carcinoma: Utilizing a novel conditional Tdg knockout mouse model containing the tamoxifen-inducible Cre-ERT2 to excise Tdg in all tissues in a temporal fashion [53], our lab demonstrated that the conditional deletion of Tdg in adult mice (TdgcKO) resulted in the development of late-onset hepatocellular carcinoma (HCC) and hepatoblastoma (HB).