The remaining eight molecular systems components (arginase signaling, CCL2 signaling, PD-L1 signaling, IDO signaling, Tim-3 signaling, TLR-2 signaling, the AHR pathway, and RANK/RANKL signaling) contribute to AML pathogenesis by promoting immune evasion and suppression. The gene discussed is IDO1; the disease is acute myeloid leukemia.