The remaining eight molecular systems components (arginase signaling, CCL2 signaling, PD-L1 signaling, IDO signaling, Tim-3 signaling, TLR-2 signaling, the AHR pathway, and RANK/RANKL signaling) contribute to AML pathogenesis by promoting immune evasion and suppression. This evidence concerns the gene HAVCR2 and acute myeloid leukemia.