Of these sixteen molecular systems components, eight of them (collagen synthesis, TGF-β signaling, CXCL12 signaling, IL-8 signaling, the OPN production pathway, VLA4 signaling, VEGF signaling, and hypoxia signaling) contribute to AML pathogenesis by promoting cell proliferation and cell survival/inhibition of apoptosis. Here, SPP1 is linked to acute myeloid leukemia.