The relative importance of MALAT1’s diverse modes of action are difficult to dissect, but since it has been shown to be one of the most frequently miR-associated transcripts in PCa (AGO-PAR-CLIP-seq identifies interactions with 600 different miRNAs in PCa cell lines) [62], its potential for therapeutic targeting may be limited by its complex interactome and anticipated broad effects of inhibition. This evidence concerns the gene FBXW7 and posterior cortical atrophy.