KLK3 and posterior cortical atrophy: In keeping with this, lncRNA CASC2 and SPRY2 were found to be down regulated while miR-183-5p was significantly upregulated in Pca tissues compared with adjacent benign tissues, and the down- and up-regulation respectively correlated with higher PSA levels, Gleason score, presence of metastases and shorter overall survival [114,116,117,118,119,120].