PCA3 and posterior cortical atrophy: In a similar mechanism of action to the above lncRNAs, PCA3 act as ceRNA to sponge miR-1261 and derepress PRKD3 (protein kinase D3) to promote invasion and migration in PCa [79] shRNA-mediated PCA3 knockdown effectively repressed the cell proliferation, invasion, migration and induced autophagy in vitro, and inhibited the tumour growth of LNCaP xenografts in vivo [79].