Isoviolanthin isolated from Dendrobium officinale reverses TGF-β1-mediated epithelial-mesenchymal transition in hepatocellular carcinoma (HCC) cells by deactivating the TGF-β/Smad and PI3K/Akt/mTOR signalling pathways [172]. The gene discussed is AKT1; the disease is hepatocellular carcinoma.