Approximately a third (27/90: 30%) had a clinical and/or genetic diagnosis of NF1, of whom all but one presented after the age of 1 year (median age at presentation 1.34 (1.94 –2.85) (range 0.91–3.00) years), and predominantly with anterior tumours (12 MDC1 and 11 MDC2 with H+ in 3 cases), few having post-chiasmatic involvement (four MDC3/4 with H+ in one case). This evidence concerns the gene NF1 and neoplasm.