Conditional deletion of Lifr reduces pancreatic tumor progression, but not ADM formation or tumor initiation in an oncogenic KRAS mouse model (Pdx1-Cre; lox-stop-lox-KrasG12D/+; Trp53lox/lox; Lifrlox/lox; lox-stop-lox-Rosa26Luc/Luc). Here, PDX1 is linked to pancreatic neoplasm.