In a KRAS-induced pancreas cell orthotopic implantation model, Rip3 deletion (KrasG12D/+; Rip−/−) leads to an increased number of T cells and decreased number of tumor-associated macrophages (TAM), indicating that necroptosis-induced CXCL1 signaling promotes immunosuppression [47]. The gene discussed is KRAS; the disease is neoplasm.