It has been however shown that conditional knockout of Cxcr4 in KPC mice (Pdx1-Cre; lox-stop-lox-KrasG12D/+; Trp53R172H/+; Cxcr4lox/lox) attenuates fibrogenesis and decreases α-SMA and PDGFR-α-positive cells but increases tumor size [55]. This evidence concerns the gene CXCR4 and neoplasm.