Pancreatic cancer patients exhibit higher GPC1+ circulating exosomes than in healthy donors, and elevated level of GPC1+ circulating exosomes is also observed in Ptf1a-Cre; lox-stop-lox-KrasG12D/+; Tgfbr2lox/lox mice [66]. Here, PTF1A is linked to familial pancreatic carcinoma.