Primary pancreatic cancer cells from Ptf1a-Cre; lox-stop-lox-KrasG12D/+; Tgfbr2lox/lox mice secrete CXCR2 ligands including CXCL1, CXCL2, and CXCL5 [22]. Here, PTF1A is linked to familial pancreatic carcinoma.