Blocking the paracrine activation of CXCR2 leads to attenuation of pancreatic tumor development, reduction of tumor angiogenesis, and prolongation of survival in Ptf1a-Cre; lox-stop-lox-KrasG12D/+; Tgfbr2lox/lox mice [22]. Here, CXCR2 is linked to pancreatic neoplasm.