Deletion of type I collagen in myCAFs by using dual-recombinase pancreatic cancer mouse model (Pdx1-Flp; frt-stop-frt-KrasG12D/+; Trp53frt/frt; Acta2-Cre; Col1a1lox/lox) accelerates pancreatic cancer progression, decreases overall survival of mice, increases Cxcl5 expression, and increases number of myeloid-derived suppressor cells (MDSCs) [21]. Here, ACTA2 is linked to familial pancreatic carcinoma.