G6PD and neoplasm: Exposure to Fak-depleted CAF cellular medium enhances glycolysis in tumor cells by upregulating glycolysis enzymes including pyruvate kinase, as well as glucose-6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase (6PGD) in the oxidative branch of pentose-phosphate pathway (PPP) [24].