These studies all found TP53 to be the most common altered gene, followed by EGFR, MET, ARID1A, MYC, NF1, BRAF, ERBB2 CTNNB1, TERT, ATM, CDKN2A, PIK3CA, CCNE1, and ARID1A in HCC. The gene discussed is CTNNB1; the disease is hepatocellular carcinoma.