Other genomic aberrations found in ctDNA of HCC patients pre-transplant include mutations in TP53, MLH1, and CTNNB1. In the evaluation of ctDNA of 895 patients with HCC, the R249S TP53 mutation encompassed 60.28% of all TP53 mutations [111]. The gene discussed is CTNNB1; the disease is hepatocellular carcinoma.