Similar to the differential diagnosis between CHL and mGZL, the at least partial preservation of the B-cell program in EBV+ DLBCL with expression of CD20 in more than 50% of HRS-like cells, presence of B-cell specific transcription factors such as Oct-2 and BOB.1 are in favor of DLBCL, as well as the positivity for EBERs in variable large- to intermediate- and small-sized cells. The gene discussed is POU2AF1; the disease is diffuse large B-cell lymphoma.