We have recently described, for the first time, an overexpression and hyper-activation of Polo-like kinase 1 (Plk1) and Aurora kinase A (AKA) in adv-SM, as compared to ISM, probably playing a key role in the pathogenesis and progression of SM (Mancini et al. submitted). The gene discussed is NEUROG1; the disease is systemic mastocytosis.