Accordingly, to investigate the role of APOL1 and its risk alleles G1 and G2 in renal carcinoma cell growth, we set up tissue culture-based studies using the RCC 786-O cell line, a primary renal cell adenocarcinoma of a Caucasian male expressing APOL1-G0, thus circumventing the toxicity of ectopic overexpression. This evidence concerns the gene APOL1 and renal cell carcinoma.