Mitochondrial swollen cristae were previously observed in normal podocytes extracted from individuals carrying APOL1 G1 and G2 alleles [20], indicating that in RCC G1 and G2, this phenotype can be unequivocally attributed to the editing of APOL1 and not to an indirect consequence of the CRISPR methodology. This evidence concerns the gene APOL1 and renal cell carcinoma.