Other proteins such as tetraspanins, RAS proteins (e.g., NRAS and RRAS), MHC proteins, complement component proteins, Src family kinases (e.g., SRC, LYN, HCK, and FGR), S100 calcium-binding proteins, and 14-3-3 proteins were found in the pleural effusion-derived MVs. The gene discussed is SRC; the disease is Pleural effusion.