The expression levels of seven proteins (CD5L, CLEC3B, SERFINF1, ITIH4, SAA4, SERFINC1, and C20ORF3 (APMAP)) were found to be significantly increased in serum-derived EVs of lung cancer patients, including AC, SCC, and small cell lung cancer (SCLC) [144]. This evidence concerns the gene ITIH4 and small cell lung carcinoma.