Proteins enriched in both A549 and HCC827 exosomes included exosome markers and associated proteins (PDCD6IP, TSG101, CD63, CD9, and SDCBP), cell adhesion proteins (DSG2, CD151, and CNTN1), receptors and signaling proteins (EGFR, SRC, EDIL3, ITGB6, JAK1, and GRB2), NSCLC-related proteins (ITGB1, BSG, SLC3A2, LAMP2, and CEACAM6), and proteases (PAPPA, CTSA, and GGT3P). Here, CEACAM6 is linked to non-small cell lung carcinoma.