On the other hand, miR-218 increased the expression of bone sialoprotein (BSP), osteopontin (OPN), and a chemokine receptor, CXCR4, in MDA-MB-231 breast cancer cells [58], suggesting that miR-218 supports osteomimicry and, thus, breast cancer cells homing to bone. The gene discussed is SPP1; the disease is breast cancer.