BRAF and brain neoplasm: In this review, we summarize the current evidence on targeted therapies with focus on v-RAF Murine Sarcoma Viral Oncogene Homolog B1 (BRAF), isocitrate dehydrogenase 1 (IDH) and neurotrophic tyrosine receptor kinase (NTRK) fusion in a precision medicine approach for adult primary brain tumors.