Conversely, it would be relevant to evaluate the importance of the eight receptors described only in a melanoma context (FZD7, GPER1, GRM3, GRM5, PAR1/F2R, CXCR4, CCR7, and CCR10), for their implication in the melanocyte lineage as a whole, whether during embryonic development, melanocyte homeostasis/renewal and/or melanogenesis. The gene discussed is F2R; the disease is melanoma.