Mitf expression is regulated by multiple signaling pathways outside of the canonical Wnt/β-catenin pathway, such as the cAMP/CREB, YAP1/PAX3, TGFβ/GLI2, and TNF/NFκB pathways, and by transcription factors, such as SOX10 and BRN2, themselves regulated by multiple pathways in melanoma. Here, MITF is linked to melanoma.