Of the 14 carriers of damaging and predicted damaging germline variants in the selected genes identified among the 543 TCGA CRC patients (Table 3), only one, an African American woman diagnosed at age 71 and carrier of the germline variant NSD1 c.4892A>G (p.K1631R), had a CRC with a somatic mutation in the same gene: c.6143T>A (p.I2048N). Here, NSD1 is linked to colorectal carcinoma.