Somatic loss-of-function NSD1 mutations are among the most prevalent lesions in human head and neck and lung squamous cell carcinomas, neuroblastomas and glioblastomas, and NSD1 gene silencing has been detected in clear cell renal cell carcinoma and urogenital cancers (reviewed by Tauchmann and Schwaller [40]). This evidence concerns the gene NSD1 and squamous cell lung carcinoma.