Lastly, NSD1 c.3151G>A (p.E1051K) was found in: a woman diagnosed with CRC at age 55 and with >70 hyperplastic/serrated polyps; in her sister, who had 16 colorectal polyps at age 61; and in one of her sons, who had two colorectal polyps at age 36. The gene discussed is NSD1; the disease is colorectal carcinoma.