NSD1 and cancer: When comparing the results to non-Finnish European, non-cancer gnomAD individuals as controls, the tendency for NSD1, KRT24 and ACACA disruptive alleles remained, and significant association was detected for KRT24 damaging and predicted damaging variants when comparing TCGA CRC patients to controls (OR = 2.57; 95% CI: 1.35–4.45; p = 0.002) (Table S7).