Somatic loss-of-function NSD1 mutations are among the most prevalent lesions in human head and neck and lung squamous cell carcinomas, neuroblastomas and glioblastomas, and NSD1 gene silencing has been detected in clear cell renal cell carcinoma and urogenital cancers (reviewed by Tauchmann and Schwaller [40]). Here, NSD1 is linked to clear cell renal carcinoma.