The aforementioned 2021 clinical study testing rAd-IFNa/Syn3 showed good response rates, especially in the cohort with papillary tumors (3-and 6- months CRs 72.9% and 62.5%) ahead of the group of patients with CIS (3- and 6-month CRs of 53.4% and 40.8%, respectively) [33]. This evidence concerns the gene IFNA2 and in situ carcinoma.