The YES1 gene, whose chromosomal location is close to the TYMS gene is amplified in 5-FU-resistant CSCs, and, after 5-FU-based neoadjuvant chemotherapy, the transcript levels of both YES and YAP are higher in liver metastases of patients with CRC and positively correlate with CRC relapse and reduced patient survival [101]. The gene discussed is YES1; the disease is colorectal carcinoma.