A recent study demonstrated that the combination of 5-FU with bromosporine, a novel BET inhibitor, induced cell cycle arrest and apoptosis in CRC cells and mouse models and that inhibition by bromosporine or knockdown of the BET protein BRD4, which is upregulated in HCT116 5-FU-resistant cells, might overcome 5-FU resistance [148]. The gene discussed is DNER; the disease is colorectal carcinoma.