PARP1 and glioblastoma: The chronic activation of PARP-1 is associated with the development of multiple malignancies of the breast, ovarian, uterine, lung, skin, and prostate, along with colorectal cancer, pediatric central nervous system cancer, Non-Hodgkin’s Lymphoma, glioblastoma multiforme, Ewing’s sarcoma, and testicular germ cell tumour [15,16].