In TKI-resistant NSCLC-derived cell lines (H1703 and SNU-1327 expressing wtEGFR, and H1975, which harbour the double L858R/T790M mutation), the inhibition of clathrin-mediated endocytosis of EGF-EGFR complexes (e.g., via dynasore [40], Filipin III [185], or Pitstop [199]) resulted in a marked increase in the fraction of TKI-induced apoptotic cells [40]. This evidence concerns the gene EGF and non-small cell lung carcinoma.