BRAF is a proto-oncogene encoding a serine-threonine protein kinase acting downstream of the RAS/RAF/ERK signalling pathway. BRAF carries signals from membrane receptors (such as EGFR) to the nucleus of the cell to regulate DNA transcription [12]. BRAF is an oncogene located on chromosome 7 involved in several cell functions, including growth, proliferation, survival, and differentiation. Immunotherapy is beginning to show promise as an active therapy in BRAF-mutated NSCLC [13]. This evidence concerns the gene BRAF and non-small cell lung carcinoma.