EGF and non-small cell lung carcinoma: Through less well-understood mechanisms, clathrin-mediated endocytosis and endosomal sorting are also involved in the transport of EGF-EGFR complexes to the close vicinity of the mitochondrial outer membrane [172] (Figure 5D), especially in highly invasive NSCLC cells [179], and to the inner nuclear membrane and the nucleoplasm [180], where EGFR functions as a co-transcription factor (Figure 5E).