MYC and non-small cell lung carcinoma: A family of three human proto-oncogenes (c-MYC, l-MYC, and n-MYC) code for transcription factors [20]. In normal cells, depending on nucleotide pools’ levels, growth signals, glucose, or oxygenation, elevated MYC expression can cause apoptosis. Transformed cells can, however, adapt to constitutively elevated levels of MYC expression, resist its apoptotic effects, and only respond to MYC pro-proliferative signals either via loss of growth suppression surveillance mechanisms (e.g., TP53 mutation) and/or by gain of pro-survival signals. MYC is a metastasis gene for NSCLC [21].