Second post-CIR time point identified cullin 7 (CUL7) and last time point acyl-coa synthetase long chain family member 4 (ACSL4) with NF2, OBSL1 and YWHAE as highly connected components, all being described or hypothesized to play roles in tumor development [77,78,79,80,81]. The gene discussed is YWHAE; the disease is neoplasm.