CD8A and neoplasm: In contrast, following TGF-β blockade or administration of IFNβ, neutrophils polarized into antitumor N1 neutrophils, characterized by cytotoxic activity towards tumor cells, reduced expression of the proangiogenic factors VEGF and MMP-9, increased expression of T cell-attracting chemokines (e.g., CCL3, CXCL9, and CXCL10), and capacity to support CD8+ T cells activation [9,68,99].