In particular, neutrophils can eliminate tumor cells through a direct cytotoxic activity mediated by the production of ROS, TNF-related apoptosis-inducing ligand (TRAIL), and nitric oxide (NO) [42,75,76,77], can act as antigen-presenting cells (APC) associated with the antitumor immune response [78,79], or can sustain type 1 polarization and antitumor activity of a subset of unconventional T cells [80]. The gene discussed is TNFSF10; the disease is neoplasm.