Interestingly, in blood isolated ctDNA were mostly assessed hyper-methylation markers (T6GALNAC3, CCDC181, HAPLN3) and the methylation level of several promoters (APC, FOXA1, GSTP1, HOXD3, RARβ2, RASSF1A, SEPT9, SOX17 ST6GALNAC3 and ZNF660) for the early detection of PCa [124,125]. Here, HAPLN3 is linked to posterior cortical atrophy.