EPCAM and neoplasm: CTCs enumeration per se had already demonstrated its great value as a predictive and prognostic biomarker; CTCs isolation can be easily achieved via positive or negative selection thanks to the expression of tumour-associated cell surface proteins, such as the epithelial cell adhesion molecule (EpCAM) or epidermal growth factor receptor (EGFR), and the lack of the leukocyte antigen cluster of differentiation 45 (CD45) [128].