A significant diagnostic value of high-risk PCa is carried also by the RT-qPCR panel established by Arkou et al., specifically investigating the expression of 14 genes (KRT19, EpCAM, CDH1, HMBS, PSCA, ALDH1A1, PROM1, HPRT1, TWIST1, VIM, CDH2, B2M, PLS3 and PSA) [137]. This evidence concerns the gene HMBS and posterior cortical atrophy.