Screening of the CYBA c.246delC and TRPM4 c.25-1 G > T variants in 1705 familial CRC cases and 1674 healthy elderly individuals, both from Poland, using custom-made Taqman assays, confirmed the presence of the CYBA variant in Family 8 and identified the CYBA c.246delC variant in four additional familial CRC cases and two healthy individuals (odds ratio 2.46, 95% confidence interval 0.48–12.69). This evidence concerns the gene TRPM4 and colorectal carcinoma.