Nodal MCL (nMCL) is the prevalent MCL subtype, accounting for 80–90% of cases, that mainly presents with the accumulation of malignant cells in the lymph nodes and extranodal sites, and is characterized by unmutated (UM) or minimally mutated IGHV, high expression of the SOX11 gene, and an aggressive clinical course. The gene discussed is SOX11; the disease is mantle cell lymphoma.