BCL2L11 and B-cell chronic lymphocytic leukemia: Like anergic B cells, CLL cells have raised basal intracellular Calcium (iCa2+) [71], reduced differentiation capacity [48,75], increased NFAT expression and ERK1/2 phosphorylation [76,77], and increased expression of the proapoptotic Bim isoforms, BimEL and BimL [78].