The first CAR against STn was reported by Hombach et al. more than 20 years ago, and few years later, McGuiness et al. demonstrated that first generation of CAR-T cells targeting STn presented antitumoral activity in two murine xenograft models of endometrial and colon adenocarcinoma [331,332]. The gene discussed is EEF1A2; the disease is colon adenocarcinoma.