In vivo experiments showing a reduction in tumor growth mediated by anti-Tn antibodies can be explained by different mechanisms: (i) antibody-dependent cellular cytotoxicity (ADCC) [20,166,168,170,182,183]; (ii) antibody-induced complement-dependent cytotoxicity (CDC) [171]; (iii) inhibition of cancer cell adhesion to lymphatic endothelium [169]; and (iv) direct blocking of receptor signaling, such as epidermal growth factor receptor and insulin-like growth factor I receptor [184]. Here, EGFR is linked to cancer.