Moreover, we evaluated the gene expression levels of the twenty-five selenoproteins and of the six HUB nodes identified in four prostate cancer cell lines compared to normal prostate epithelial cells, selecting three selenoproteins (GPX2, EP300 and PSMB2), whose collective expression correlated with the overall survival of prostate cancer patients, suggesting that only the combined evaluation of some selenoproteins and HUB nodes could have prognostic value and may improve patient outcome prediction [12]. This evidence concerns the gene EP300 and Familial prostate cancer.