Interestingly, we found significant heterogeneity in SAMHD1 expression across different tumor types, from 100% positivity for rectal cancer, through 68% in ovary, 61% in breast, 50% in NSCLC and 11% in pancreatic cancer, similar to available data from public databases, except for rectal cancer, where the distinct methodology used for its evaluation may influence in the high positivity observed. The gene discussed is SAMHD1; the disease is familial pancreatic carcinoma.