In contrast, increased SAMHD1 mRNA expression has been associated with metastasis in colon cancer [15], and higher SAMHD1 serum levels have been associated with NSCLC cancer progression [16]; therefore, suggesting that low SAMHD1 expression might also represent a favorable prognostic factor in certain cancers [17]. The gene discussed is SAMHD1; the disease is malignant colon neoplasm.