While our syngeneic orthotopic model showed Kindlin-2 in MECs was critical in BC cancer progression and metastasis, it remains to be seen whether this effect would be maintained in mouse models that develop BC spontaneously, such as the MMTV-PyMT [36], MMTV-Myc [37] and MMTV-Wnt1 [38] models. This evidence concerns the gene WNT1 and breast cancer.