PTGS2 and infectious otitis media: Subsequent studies confirmed the role of FO in preventing AOM-induced colon carcinogenesis through enhanced cell differentiation and apoptosis [50], particularly when compared to diets containing a mixture of lipids simulating the Western diet (lipids derived from saturated fats, peanut and corn oils) [51] and suggested that the effect could be mediated via reduced cyclooxygenase-2 (COX-2) activity and prostaglandin production.