IFNG and neoplasm: Early studies of “mechanical” focused ultrasound in colon adenocarcinoma and prostate tumours showed that pHIFU treatments using an H-102 HIFU transducer (Sonic Concepts, Seattle, WA, USA) induced DC maturation and the accumulation of tumour-specific IFNγ-secreting cells, and increased Tcytotoxic responses (parameters:P– = 10–12.5 MPa, d.c. = 2%) [117,118].