IFNG and neoplasm: In vivo, treatment of murine hepatocellular tumours with “thermal” ablative focused ultrasound using a 2-cm-diameter transducer has doubled the cytotoxic activity of T cells, increased the secretion of IFNγ and TNFα [115] and produced a statistically significant maturation of DC and subsequent activation of Tcytotoxic cells against the tumours (parameters:f = 9.5 MHz, Power = 5 W, exposure time = 220 s) [111].