SPRED1 and cancer: One group observed multiple CALMs in NF1, which is also associated with such non-tumoral manifestations as skinfold freckling and iris Lisch nodules [101], and in other cancer predisposing syndromes such as legius syndrome, caused by mutated SPRED1 [102], McCune–Albright syndrome, Bloom syndrome, Fanconi anemia, tuberous sclerosis, and ataxia-telangiectasia [103].