SMAD4 and hereditary mixed polyposis syndrome: Other inherited CRC genes include BMPR1A and SMAD4, which lead to juvenile polyposis (#174900); PTEN, which leads to PTEN hamartoma tumor syndrome (PHTS; (#158350); AXIN2, which leads to oligodontia-colorectal cancer syndrome (#608615); STK11-Associated Peutz–Jeghers Syndrome (#175200), GREM1, which leads to hereditary mixed polyposis syndrome (HMPS; (#601228); and POLD1 and POLE, which lead to polymerase proofreading-associated polyposis (PPAP; (#615083).