The nonmalignant features identified in patients with FAP and AFAP, caused by germline mutations in APC, and oligondotia–CRC syndrome, caused by alterations in AXIN2, point to the involvement of the Wnt signaling pathway, a primordial instructive genetic program that is evolutionarily conserved throughout the animal kingdom [107]. This evidence concerns the gene APC and Familial adenomatous polyposis.