DNA amplifications take place in chromosome regions 11q13 and 6p21, affecting the oncogene cyclin D1 (CCND1) and neoangiogenic vascular endothelial growth factor A (VEGFA) respectively, inducing the latter tumor proliferation through the secretion of macrophage-mediated hepatocyte growth factor (HGF) [22,23]. Here, HGF is linked to neoplasm.