The list of ectoproteases as potential targets for cancer therapy is further expanding, as has already been seen with other ADAMs (including ADAM8, ADAM10, ADAM28), MT1-MMP/MMP14, the complex urokinase plasminogen (uPA)/uPAR, and neutral endopeptidase N/CD10 overexpressed in solid and haematological tumours [19,101,290,291]. The gene discussed is PLAUR; the disease is cancer.