With regard to proMMP2 targeting, Sarkar et al. [228] recently developed a cyclic peptide (cy(WPHPY)) which binds to proMMP2 and disrupts the interaction between proMMP2 and TIMP-2, thereby preventing TIMP2-mediated proMMP2 activation and inhibiting cell invasion of human melanoma cells [228]. Here, TIMP2 is linked to melanoma.