CD4 and hepatocellular carcinoma: In addition, we also found that FOXP3+ cell density was slightly higher than that of CD4+ cells in intratumoral immune cells, suggesting FOXP3+ cells could be the part of CD8+ T cells, and FOXP3+ CD8+ T cells subpopulation may contribute to UrC immune escape and disease progression, which have been described in hepatocellular carcinoma [34].