Meanwhile, PD-L1 expression on immune cells might potentiate enhanced immunosuppression by impairing the secreting cytokines function of CD8+ T cells, which is associated with tumor progression and poor prognosis [46], and consistent with our result that tumors with high densities of peritumoral CD8+ T cells had a worse prognosis than those with low or mid densities. Here, CD274 is linked to neoplasm.