Therefore, we speculated that HLA-DR+ cells in intratumoral and peritumoral immune cells of UrC could more likely represent CD4+ or CD8+ T cells belonging to immunosuppressive subtype and immature DC that have a reduced capacity to stimulate T-cells, which somewhat underscores the importance of inefficient antigen presentation as a mechanism for tumor evasion. This evidence concerns the gene CD4 and neoplasm.