In addition, LMP1 can inhibit IFN-β expression through promoting RIG-I degradation in nasopharyngeal carcinoma (NPC) cell line C666-1, suggesting that LMP1 may recruit CHIP E3 ligase to degrade RIG-I through the ubiquitin–proteasome system [55]. The gene discussed is STUB1; the disease is nasopharyngeal carcinoma.