BRCA1 and breast carcinoma: It is now estimated that 10–25% of breast carcinomas are associated with HRD [11,12,13], due to BRCA1/2 PV [14,15,16,17], but also of other genes such as PALB2, ATM, ATR, BARD1, RAD51, BRIP1, or FANC [18,19,20,21].