ASPG and extranodal nasal NK/T cell lymphoma: Regimens incorporating L-asparaginase or pegylated asparaginase including SMILE [65,78], AspaMetDex (L-asparaginase, methotrexate, and dexamethasone) [79], MEDA (methotrexate, etoposide, dexamethasone and pegylated asparaginase) [80] and P-GEMOX [81] have been evaluated in patients with newly diagnosed advanced-stage NK/T-cell lymphomas.