ACO2 and posterior cortical atrophy: This pathway exhibited two different metabolic shifts: a first one defined by the upregulation of most of TCA enzymes during initial PCa stages, and a second metabolic shift during PCa progression, involving the downregulation of ACO2, oxoglutarate dehydrogenase (OGDH), and succinate-CoA ligase alpha subunit (SUCLG1), together with elevated expression of malate dehydrogenase 2 (MDH2).