In this study, the analysis of the expression levels of several metabolic coregulators in five different PCa datasets revealed that only alterations in the transcriptional coactivator PPARG coactivator 1 alpha (PPARGC1A or PGC1A), PPARG coactivator 1 beta (PPARGC1B or PGC1B), and histone deacetylase 1 (HDAC1) expression were present in the majority or all datasets. The gene discussed is HDAC1; the disease is posterior cortical atrophy.