For example, EGFR-associated IGAS genes were significantly enriched in multiple signaling pathways, such as PI3K-Akt signaling pathway, VEGF signaling pathway, and p53 signaling pathway, while RBM5- and SRSF5-associated IGAS genes were significantly enriched in primary immunodeficiency and biosynthesis of cofactors, respectively. Here, RBM5 is linked to inborn error of immunity.