For example, EGFR-associated IGAS genes were significantly enriched in multiple signaling pathways, such as PI3K-Akt signaling pathway, VEGF signaling pathway, and p53 signaling pathway, while RBM5- and SRSF5-associated IGAS genes were significantly enriched in primary immunodeficiency and biosynthesis of cofactors, respectively. The gene discussed is AKT1; the disease is inborn error of immunity.