However, it should also be considered that morning cortisol assessment and ACTH stimulation test may not be informative in some conditions, such as in patients treated with oestrogens, nephrotic syndrome, inappropriate Cosyntropin dilution, acute ACTH deficiency (e.g., hypophysitis acute phase, brain surgery or trauma), critical illness or when tests are not performed at the right time (8.00 A.M.). This evidence concerns the gene POMC and nephrotic syndrome.