Immunological profiling of 84 inflammatory molecules and their receptors in PBMCs of treatment-naïve ductal breast carcinoma patients, including 23 TNBC (ER-/PR-/HER2-) and 17 Her2-luminal (ER+/PR+/HER2-), revealed that TNBC patients had altered expression of PBMC genes associated with immunological status and presented with lower counts of lymphocytes and eosinophils than the ER+/PR+/HER2- patients [12]. Here, ESR1 is linked to breast ductal adenocarcinoma.