The gene expression signature of immune activation and cytotoxicity (FGFBP2 + GNLY + GZMB + GZMH + NKG7 + LAG3 + PDCD1 − HLA-G) in CD8+ PD-1HI T-cells of TNBC patients and in post-NAC whole blood of BC patients was associated with persistent disease following chemotherapy and disease recurrence after surgery [107,108]. Here, PDCD1 is linked to breast cancer.