Further, genes associated with the Wnt/β-catenin pathway, such as CTNNB1, AXIN1, or HNF4A, were mutated only in hypervascular aHCC regions with relatively high variant allele frequencies, suggesting that these were associated with tumor progression from hypovascular to hypervascular HCC in the cohort. The gene discussed is CTNNB1; the disease is hepatocellular carcinoma.