Among patients with extreme insulin resistance:INSR−/− vs. INSR+/− vs. LD: TV 10 ± 5 vs. 4 ± 2 vs. 6 ± 3 mL (p < 0.05); fasting insulin 626 ± 390 vs. 136 ± 124 vs. 64 ± 121 μU/mL (p < 0.05). This evidence concerns the gene INS and Insulin resistance.