In xenografted ovarian tumors, ARHI1 expression induces autophagy by inhibiting the PI3K/AKT/mTOR pathway and supporting nuclear localization of the transcription factor EB (TFEB) and Forkhead box O3 (FOXO3a), which in turn mediate the expression of crucial autophagy effectors [56]. This evidence concerns the gene TFEB and ovarian neoplasm.