In mouse models, inflammation-derived proteases, neutrophil elastase, and matrix metalloproteinase-9 can induce proliferation in dormant cells by cleaving extracellular laminin and exposing a specific epitope that triggers an integrin-mediated signaling cascade in cancer cells, finally reactivating the proliferation of dormant cancer cells at sites of metastasis [91]. This evidence concerns the gene MMP9 and cancer.