Interestingly, La and collaborators showed that the proto-oncoprotein c-Myc, which usually drives malignant cell cycle progression, is expressed at relatively high levels in p27highKi67low quiescent melanoma cells, where it selectively transactivates OXPHOS-related genes, including subunits of isocitric dehydrogenase 3 (IDH3), while its binding to cell cycle progression gene promoters is reduced in quiescent cells [144]. The gene discussed is MYC; the disease is melanoma.