VCAM1 and neoplasm: In agreement with the essential role of neutrophils in tumor angiogenesis, reduced tumor vascularization and growth have been demonstrated after antibody-mediated neutrophil depletion (using anti-Gr-1 or anti-Ly6G antibody) or inhibition of neutrophil infiltration into tumor tissue (e.g., anti-vascular cell adhesion molecule-1 and anti-VCAM-1) in several studies [32,97,100].