In animal models, Zhou et al. [127] demonstrated that S1P-S1PR1 signalling promotes gastric cancer progression by increasing the expression of cytokines and recruitment of myeloid-derived suppressor cells to the tumour microenvironment, thus impairing the anti-tumour functions of the tumour-infiltrating lymphocytes (TILs). The gene discussed is MBTPS1; the disease is neoplasm.