In their mouse model, SphK1−/−/KO, HNSCC was significantly reduced, and they speculated that SphK1 activation was required to induce proinflammatory cytokines (including the interleukins IL-1b and IL-6) in the mediation of inflammation-related HNSCC cancer development [100]. The gene discussed is IL6; the disease is head and neck squamous cell carcinoma.