TGFB1 and neoplasm: Moreover, signaling factors like the TGF-β or autocrine stimulatory loop signaling via EGFR have been demonstrated to promote tumor invasiveness [27,28] by causing a shift in cell adhesion properties of tumor cells, mainly through the downregulation of protease inhibitors, upregulation of protease secretion, or by causing a general increase in cell motility [5,28,29,30].