In line with these findings, inhibition of the HIF-1α/VEGF axis by both synthetic and natural chemicals such as bisphosphonates, farnesyltransferase inhibitors, epigallocatechin-3-gallate, and dauricine suppressed IGF-I-induced angiogenesis in breast cancer, lung cancer, and HNSCC cells [219,224,225,226]. This evidence concerns the gene VEGFA and breast cancer.