For example, PCa patient EV expressed genes dysregulated or altered in PCa and/or metastasis (e.g., FNLA, MMP16, CDON, NRP2, PAX5, SULT1B1, L1CAM, SCHBP1) [77,78,79,80,81,82,83,84], in castration resistant prostate cancer (DPY19L2, NOVA1, NOVA2) [85,86] and in enzalutamide resistant (SLC6A15) [87] or androgen independent PCa cells (CALN1) [88]. Here, CALN1 is linked to posterior cortical atrophy.